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Based on the earlier discussed receptor expression, innervation and their crucial role in behavioral control two mesolimbic nuclei, the VTA and the NAc, became the first targets of studies exploring behavioral consequences of the mesolimbic GLP-1R activation

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The overlap with the comparison compound is worth noting: researchers interested in berberine and semaglutide together will find very similar mechanistic logic applies to the tirzepatide combination, since semaglutide is a GLP-1 receptor agonist and tirzepatide adds GIP receptor agonism on top